Research

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Intl School on Hypercomplex Numbers, Lie Groups and Applications

Subject: Intl  School on Hypercomplex Numbers, Lie Groups and Applications





Dear Colleague,

It is my pleasure to inform you
about the  Intl  Summer School on

   Hypercomplex Numbers,
Lie Groups, and Applications

to be held in  Varna, June 9-12, 2017.


For more detail, please visit the
webpage of the meeting at

http://www.bio21.bas.bg/conference/school

Besides the Lectures  Corses that will be delivered
by  the wellknown experts, there would be
some slots for talks by the participants.

We plan  also to publish as a separate
volume both the Lecture Courses
and the contributed Talks before
the end of this year.

Registered participant will receive
this volume for free.

Details about the Registration are
given on the webpage of the School.

Please, notice that the School will be
preceded by the  XIX-th Edition of the
annual Conference on

Geometry, Integrability and Quantization

which will take place in June 2-7, 2017.

see

http://www.bio21.bas.bg/conference

Looking  forward  to meet  you in Varna,
I remain,

Sincerely yours,

                        Ivailo Mladenov
==============================

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web: http://www.bio21.bas.bg/ibf/dpb_files/im/Mladenov.htm
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Team identifies ‘switch’ involved in DNA replication


DNA replication is an extraordinarily complex multi-step process that makes copies of the body’s genetic blueprint. It is necessary for growth and essential to life.

Now researchers at the California Institute of Technology (Caltech) and Vanderbilt University have found evidence that one of those steps may involve the telephone-like transmission of electrical signals regulated by a chemical “switch.”

Conventional telephones convert sound waves into electrical signals that can be transmitted vast distances through wire, and which are then converted back into audible sound at the receiving end.

A similar form of communication may be required to achieve DNA replication. Only in this case the telephone wire is DNA and the telephones are unique clusters of four iron and four sulfur atoms within the multi-protein “machines” that copy it in a highly coordinated fashion.

This model of replication has not yet been proven. But in a report published this week by the journal Science, the Caltech/Vanderbilt team demonstrates the existence of the chemical switch that they believe plays a central role in enabling our genes to be copied efficiently.

“We propose this as a fundamentally new transformative idea about how you could get communication between proteins over very long spatial distances using DNA as a wire,” said Walter Chazin, Ph.D., the Chancellor’s Professor of Medicine, professor of Biochemistry and Chemistry and director of the Vanderbilt Center for Structural Biology.

“This chemistry provides a means of long range, rapid communication for processing genomic DNA,” added Jacqueline K. Barton, Ph.D., the John G. Kirkwood and Arthur A. Noyes Professor of Chemistry at Caltech and the paper’s co-corresponding author with Chazin.

Barton, who chairs the Division of Chemistry and Chemical Engineering, has spent decades studying DNA charge transport — the transmission of electricity through DNA — as a verifiable and biologically important phenomenon.

In 2007, Chazin and his colleagues reported finding a cluster of four iron atoms and four sulfur atoms within the protein human DNA primase, the enzyme that “primes” or readies the DNA template before full copies of the DNA can be made.

Iron-sulfur clusters are known to drive oxidation-reduction (redox) reactions, a type of chemical reaction that involves the transfer of electrons and which provides the energy for a wide range of biochemical processes. But what role these clusters played in DNA replication and other DNA transformations was not known.

Barton believed that iron-sulfur clusters could be used for DNA charge transport in cells and teamed up with the Chazin lab to prove this is important for copying genes.

In the current study, the researchers showed that the oxidative state of DNA primase — the number of electrons held by its iron-sulfur cluster — affects how strongly it binds to DNA. The iron-sulfur cluster thus acts as a “redox switch” to coordinate one of the critical steps of DNA replication.

The next step of this research is to show that DNA charge transport driven by iron-sulfur clusters enables DNA replication proteins to communicate with each other and synchronize their actions.

Iron-sulfur clusters are found in the multi-protein machines that perform virtually all transformation of DNA. Defects in any of these machines can lead to mutation, genome instability and ultimately cancer, neurological disorders and other diseases.

Understanding how DNA processing machines work could lead to fundamentally new avenues for the development of targeted therapies.

Study co-authors were Caltech graduate student Elizabeth O’Brien, Vanderbilt graduate students Marilyn Holt and Lauren Salay and Vanderbilt postdoctoral fellows Matthew Thompson, Ph.D., and Aaron Ehlinger, Ph.D.

The research was supported in part by National Institutes of Health grants GM061077, GM120087, GM065484 and GM118089, and training grant GM08320.

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Intl School on Hypercomplex Numbers, Lie Groups and Applications

Subject: Intl  School on Hypercomplex Numbers, Lie Groups and Applications





Dear Colleague,

It is my pleasure to inform you
about the  Intl  Summer School on

   Hypercomplex Numbers,
Lie Groups, and Applications

to be held in  Varna, June 9-12, 2017.


For more detail, please visit the
webpage of the meeting at

http://www.bio21.bas.bg/conference/school

Besides the Lectures  Corses that will be delivered
by  the wellknown experts, there would be
some slots for talks by the participants.

We plan  also to publish as a separate
volume both the Lecture Courses
and the contributed Talks before
the end of this year.

Registered participant will receive
this volume for free.

Details about the Registration are
given on the webpage of the School.

Please, notice that the School will be
preceded by the  XIX-th Edition of the
annual Conference on

Geometry, Integrability and Quantization

which will take place in June 2-7, 2017.

see

http://www.bio21.bas.bg/conference

Looking  forward  to meet  you in Varna,
I remain,

Sincerely yours,

                        Ivailo Mladenov
==============================

=============
web: http://www.bio21.bas.bg/ibf/dpb_files/im/Mladenov.htm
===========================================
PS If you prefer not to receive such
alerts in the future, just respond to
this message by writing

         "Remove"

in the main body of the letter.
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Lasers Could Give Space Research its 'Broadband' Moment

http://www.jpl.nasa.gov/images/technology/20170214/tech20170214-16.jpg


Thought your Internet speeds were slow? Try being a space scientist for a day.


The vast distances involved will throttle data rates to a trickle. You're lucky if a spacecraft can send more than a few megabits per second (Mbps).

But we might be on the cusp of a change. Just as going from dial-up to broadband revolutionized the Internet and made high-resolution photos and streaming video a given, NASA may be ready to undergo a similar "broadband" moment in coming years.

The key to that data revolution will be lasers. For almost 60 years, the standard way to "talk" to spacecraft has been with radio waves, which are ideal for long distances. But optical communications, in which data is beamed over laser light, can increase that rate by as much as 10 to 100 times.

High data rates will allow researchers to gather science faster, study sudden events like dust storms or spacecraft landings, and even send video from the surface of other planets. The pinpoint precision of laser communications is also well suited to the goals of NASA mission planners, who are looking to send spacecraft farther out into the solar system.

"Laser technology is ideal for boosting downlink communications from deep space," said Abi Biswas, the supervisor of the Optical Communications Systems group at NASA's Jet Propulsion Laboratory, Pasadena, California. "It will eventually allow for applications like giving each astronaut his or her own video feed, or sending back higher-resolution, data-rich images faster."

Science at the speed of light

Both radio and lasers travel at the speed of light, but lasers travel in a higher-frequency bandwidth. That allows them to carry more information than radio waves, which is crucial when you're collecting massive amounts of data and have narrow windows of time to send it back to Earth.

A good example is NASA's Mars Reconnaissance Orbiter, which sends science data at a blazing maximum of 6 Mbps. Biswas estimated that if the orbiter used laser comms technology with a mass and power usage comparable to its current radio system, it could probably increase the maximum data rate to 250 Mbps.

On Earth, data is sent over far shorter distances and through infrastructure that doesn't exist yet in space, so it travels even faster.

Increasing data rates would allow scientists to spend more of their time on analysis than on spacecraft operations.

"It's perfect when things are happening fast and you want a dense data set," said Dave Pieri, a JPL research scientist and volcanologist. Pieri has led past research on how laser comms could be used to study volcanic eruptions and wildfires in near real-time. "If you have a volcano exploding in front of you, you want to assess its activity level and propensity to keep erupting. The sooner you get and process that data, the better."

That same technology could apply to erupting cryovolcanoes on icy moons around other planets. Pieri noted that compared to radio transmission of events like these, "laser comms would up the ante by an order of magnitude."

Clouding the future of lasers

That's not to say the technology is perfect for every scenario. Lasers are subject to more interference from clouds and other atmospheric conditions than radio waves; pointing and timing are also challenges.

Lasers also require ground infrastructure that doesn't yet exist. NASA's Deep Space Network, a system of antenna arrays located across the globe, is based entirely on radio technology. Ground stations would have to be developed that could receive lasers in locations where skies are reliably clear.

Radio technology won't be going away. It works in rain or shine, and will continue to be effective for low-data uses like providing commands to spacecraft.

Next steps

Two upcoming NASA missions will help engineers understand the technical challenges involved in conducting laser communications in space. What they'll learn will advance lasers toward becoming a common form of space communication in the future.

The Laser Communications Relay Demonstration (LCRD), led by NASA's Goddard Space Flight Center in Greenbelt, Maryland, is due to launch in 2019. LCRD will demonstrate the relay of data using laser and radio frequency technology. It will beam laser signals almost 25,000 miles (40,000 kilometers) from a ground station in California to a satellite in geostationary orbit, then relay that signal to another ground station. JPL is developing one of the ground stations at Table Mountain in southern California. Testing laser communications in geostationary orbit, as LCRD will do, has practical applications for data transfer on Earth.

Deep Space Optical Communications (DSOC), led by JPL, is scheduled to launch in 2023 as part of an upcoming NASA Discovery mission. That mission, Psyche, will fly to a metallic asteroid, testing laser comms from a much greater distance than LCRD.

The Psyche mission has been planned to carry the DSOC laser device onboard the spacecraft. Effectively, the DSOC mission will try to hit a bullseye using a deep space laser -- and because of the planet's rotation, it will hit a moving target, as well.

http://go.nasa.gov/2gBzbyx

UPDATED AT 10:40 a.m. PST on 2/15/17 to clarify relative data speeds.

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NASA to Host News Conference on Discovery Beyond Our Solar System

 


NASA will hold a news conference at 10 a.m. PST (1 p.m. EST) Wednesday, Feb. 22, to present new findings on planets that orbit stars other than our sun, known as exoplanets. The event will air live on NASA Television and the agency's website.

Details of these findings are embargoed by the journal Nature until 10 a.m. PST (1 p.m. EST).

Media and the public also may ask questions during the briefing on Twitter using the hashtag #askNASA.

The briefing participants are:

• Thomas Zurbuchen, associate administrator of the Science Mission Directorate at NASA Headquarters in Washington

• Michael Gillon, astronomer at the University of Liege in Belgium

• Sean Carey, manager of NASA's Spitzer Science Center at Caltech/IPAC, Pasadena, California

• Nikole Lewis, astronomer at the Space Telescope Science Institute in Baltimore

• Sara Seager, professor of planetary science and physics at Massachusetts Institute of Technology, Cambridge

A Reddit AMA (Ask Me Anything) about exoplanets will be held following the briefing at noon PST (3 p.m. EST) with scientists available to answer questions in English and Spanish

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SCIENCE_Colloquium on 4th of Esfand

 Colloquium


Dear all, 
It is a pleasure for me to announce that the speaker of the  next colloquium  is  Dr Abbas Saberi of Tehran Univ. More information can be found in the textbox to the right.


Everybody is welcome to attend.


With kind regards,
Y. Farzan


Speaker

Dr Abbas Saberi

Affliation

Tehran Univ

Title of talk

Violation of the second law of thermodynamics and its consequences
«نقض قانون دوم ترمودینامیک و پیامد های آن»

Date and time

Wednesday, 4th of Esfand (22th of February), 4:30 pm

Place

Farmanieh builing, lecture room C

IPM

Abstract



چکیده سخنرانی:
   یکی از دلایلی که نقض قانون دوم ترمودینامیک در زندگی روزمره مشاهده نمی شود، خاصیت ظهوری برآمده از آمار بالا است، یعنی وجود تعداد بسیار بالای درجات آزادی از مرتبه عدد آووگادرو. بنابراین ما هیچ وقت، به عنوان مثال، شاهد آن نیستیم که یک مقاومت الکتریکی به یک مدار انرژی بدهد.
اما در سیستم های کوچک، افت و خیزهای آماری
به شدت غالب می شوند که نقش بسیار تعیین کننده ای در توصیف رفتار سیستم های غیرتعادلی ایفا می کنند.

در این سخنرانی، پس از مرور کلی بر ترمودینامیک غیرتعادلی، مثالی از مشاهده نقض قانون دوم را خواهیم دید که به طرز جالبی منجر به استخراج اطلاعات تعادلی برای یک سیستم دور از تعادل می گردد.

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Hep_ Workshop march 14-16



We will have a small workshop on recent developments in string theory, field theory and higher-spin theory in the light-front approach


https://sites.google.com/view/lightfrontworkshop/home


Anybody interested is very wellcome


Best wishes

Ivo

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Electrical brainstorms traced to genetic mutations

Shareline

Researchers from Seattle Children’s and Novartis shed light on intractable epilepsy.

Electrical signals pulse through the gray matter of your brain, allowing you to read and understand this sentence. The cerebral cortex—home to your gray matter—is packed with more than 20 billion neurons, which are organized into circuits.1 Collectively, these circuits are the seat of human cognition. And the results can be dire when they don’t form properly.

Take children with a disease called focal cortical dysplasia (FCD). Born with an enlarged, disorganized area of the cortex, these patients often experience seizures, brainstorms of uncontrolled electrical activity that can lead to developmental delays and disabilities. In fact, FCD is the most common cause of intractable epilepsy in children.2 For years, researchers speculated about the underlying mechanisms of the disease. Could a virus be triggering the brain overgrowth? Or maybe the tissue had been bumped and bruised during pregnancy?

Scientists now believe that many cases of FCD have genetic roots. Collaborators from Seattle Children’s Research Institute (link is external), the Novartis Institutes for BioMedical Research and other organizations recently traced four cases of FCD to genetic mutations, publishing their findings online in JAMA Neurology (link is external). Specifically, the team identified mutations in a molecular pathway called mTOR, which plays an essential role in regulating cell growth. The researchers also found MTOR mutations in six patients with more widespread, diffuse brain overgrowth. The discovery bolsters a growing body of evidence (link is external) that such diseases can be genetic and suggests new treatment approaches.

“We found that there are genetic changes in the brain tissue of these patients and showed that the changes are related to the structural abnormalities that occur in the brain,” says first author Ghayda Mirzaa, a physician-scientist at Seattle Children’s Research Institute. “Now we have a chance to test molecularly-targeted therapies in epilepsy.”

Clues in patient tissue

Mirzaa’s colleague William Dobyns (link is external), last author on the new study, began building a registry of patients with FCD and other brain overgrowth disorders in 1990. The goal was to learn more about them and identify new therapeutic approaches.

By 2012, the research team at Seattle Children’s Hospital, in collaboration with the neurosurgical team, led by Jeff Ojemann, had gathered tantalizing clues by studying brain tissue from the patients. Some children with the disorders undergo epilepsy surgery, a treatment of last resort and a source of invaluable samples. If patients fail to respond to anti-epilepsy medication, then neurosurgeons may remove the portion of the cortex that’s generating abnormal electrical activity in an attempt to block further seizures. This precious tissue gives scientists a window into the disorders.

Biochemical tests indicated that the mTOR pathway was overactive in many of the samples. DNA sequencing revealed mutations (link is external) in key components of the pathway, but only in patients with diffuse brain overgrowth. The mutations didn’t show up in any patients with FCD.

Mirzaa and Dobyns, who are also clinical geneticists at Seattle Children’s Hospital, suspected that the mutations were simply hiding due to a quirk of biology. High school students learn that an individual’s DNA is determined when sperm and egg meet. But this is an oversimplification. While DNA is generally replicated faithfully as cells divide in a developing embryo, there are some exceptions. As a result, two or more populations of cells with different DNA can exist in the same organism, a phenomenon known as mosaicism.

The Seattle Children’s researchers wondered if there was a small population of neurons with mTOR mutations in FCD patients. Perhaps the population was so small that the mutations weren’t registering with standard DNA sequencing techniques.

Uncovering hidden mutations

Luckily, Wendy Winckler’s next-generation sequencing group in Oncology at Novartis had the tools to test the hypothesis.

“Being a cancer sequencing lab, we specialize in finding mutations that only occur in a small fraction of cells,” says Winckler. “A tumor is a mix of normal cells, immune cells and cancer cells, so we have to be able to detect low-level mutations in samples.”

Zeroing in on protein-coding genes, her group performed deep sequencing on the samples, reading tens of thousands of cells in each one. The team also sequenced tissue from the patients’ parents and from the periphery of the patients (blood, saliva or skin) so that they had a basis for comparison. Bioinformatician Katie Campbell then analyzed the data.

“We’ve tuned our software to catch mutations that occur in less than 5 percent of the cells,” explains Campbell. “We also have experience finding mTOR mutations because they’re relatively common in tumors, given that the pathway regulates cell growth.”

Campbell analyzed samples from eight patients with FCD and their parents. She identified mTOR pathway mutations—including genetic lesions identical to those seen in cancer patients—at a low level in four of the FCD patients. Researchers at Seattle Children’s Hospital and the University of Washington Genome Sciences Center used targeted sequencing and deep sequencing to screen 93 additional children with unexplained FCD or diffuse brain overgrowth. They found mTOR pathway mutations in six of the patients with diffuse brain overgrowth, suggesting that it’s related to FCD.

In parallel, Novartis scientists within the Developmental & Molecular Pathways and Neuroscience groups set out to determine exactly how the mutations affect brain cells. Carleton Goold, Sue Menon and their teams introduced them into rat neurons, which proceeded to grow very large. The researchers also tested mTOR pathway activity in the neurons and confirmed that it was elevated.

The final step was to rescue the swollen cells. When the team applied an mTOR inhibitor to the mutant neurons, the cells shrank to a healthy size, pointing toward a potential therapeutic strategy for patients.

“This pathway is extremely well known in the cancer space, but now it’s coming up as an important target in neuroscience,” says Leon Murphy, who led the validation effort at Novartis. “I think that we’re going to see mTOR popping up in other areas as well. It might be possible to repurpose cancer drugs for these diseases based on preclinical data and potentially provide patients with more options at some point.”

Researchers introduced an mTOR mutation identified from focal cortical dysplasia patients into these rat neurons. The neurons are enlarged, similar to what is seen in brain tissue from the patients. Image by Jonathan Biag/Novartis


  1.  Pelvig, D. P., Pakkenberg, H., Stark, A K., and Pakkenberg, B. (2008). Neocortical glial cell numbers in human brains. Neurobiol. Aging 29, 1754–1762.
  2.  Kabat, J. and Krol, P. (2012). Focal cortical dysplasia – review. Pol J Radiol. Apr-Jun; 77(2): 35–43.
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[Hep] [call-for-proposals] MITP Summer School 2017 "Joint Challenges for Cosmology and Colliders"

Dear colleagues

We are pleased to announce the second Mainz Institute for Theoretical Physi cs graduate summer school, "Joint Challenges for Cosmology and Collide rs," to be held in downtown Mainz from August 7-25, 2017. The school is aimed at advanced graduate students in theoretical high en ergy physics from Europe and abroad, who are in the research stages of thei r graduate careers.

The lecturers for our 2017 school and their topics are:
Evgeny A khmedov (MPI Heidelberg) - Neutrino Phe nomenology
Nima Ark ani-Hamed (IAS) - Collider Phy sics from the Bottom Up
Matthias Bartelmann (U. of Heidelberg) - Lambda CDM a nd Early Universe Cosmology
Brian Ba tell (U. of Pittsburgh) - Laboratory P robes of Dark Matter and Neutrinos
Marcela Carena (FNAL/U. of Chicago) - CP Violation and the Baryogenesis Puzzle
Stefania Gori (U. of Cincinnati) - Beyond the S tandard Model Phenomenology
Christop he Grojean (DESY) - Standard Mod el, Electroweak Symmetry Breaking, and the Higgs Boson
Andreas Ringwald (DESY) - Axions and A xion-Like Particles
Tracy Sl atyer (MIT) - CMB and Astr ophysical Probes of Dark Matter
LianTao Wang (U. of Chicago) - Dark Matter at the Collider
Neal Wei ner (NYU) - Dark Matter Model Building

Applicants should have basic knowledge of quantum field theory and the S tandard Model and are expected to attend the entirety of the three weeks.&n bsp; Applications are now open at https://indic o.mitp.uni-mainz.de/event/88/page/1 , and the application deadline is 31 March 2017. Successful applicants will be notified shortly thereafter. We anticipate 50 students will be accepted for the school. The cost for the three w eek program, including full board (except lunch and dinner on weekends), sh ared housing (two persons to a room), and coffee breaks, is 980 EUR. (Single rooms can be secured at an additional co st of 150 EUR.) In addition to the lecture series indicated above, we are also planning a vibrant social program and informal discussion session s with the lecturers. Please find more information on our Indico site, https://indico.mitp.uni-mainz.de/event/88 .&nbs p; Mainz is located approximately 45 minutes by train west of Frankfurt in Germany. The Mainz Institute for Theoretical Physics is part of the Excellence Cluster "PRISMA" and is locate d in the Johannes Gutenberg University, Mainz.

Please forward this announcement to anyone who may be interested. For any questions, please contact us at theory school2017@uni-mainz.de

Sincerely yours,
The MITP 2017 graduate summer school organizing committee
Anna Kaminska, Joachim Kopp, Matthias Neubert, Maikel de Vries, Felix Yu


Mainz Institute for Theoretical Phys ics
PRISMA Cluster of Excellence
Johannes Gutenberg University Mainz
Staudingerweg 9
55128 Mainz
www.mitp.uni-mainz.de

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Metabolic Imaging in Neurodegenerative Disease Using CEST MRI

alt_text

Seminar Overview:

Chemical Exchange Saturation Transfer (CEST) imaging has emerged over the past decade as a new and innovative MRI contrast method, specifically designed for molecular imaging. This original approach can detect small amounts of contrast agent through saturation of fast exchanging protons, allowing for a larger number of imaging schemes and techniques. CEST particularly benefits from high magnetic fields, such as 11.7T in the research presented.

Thanks to optimization of the saturation parameters (e.g. saturation intensity, offset and duration), it is possible to probe different exchanging protons. Thus, CEST offers the possibility to detect a large variety of metabolites including glutamate, glucose, or creatine. This confers to CEST the potential to provide valuable clues about various pathological features in a single experiment.

In this webinar, Dr. Julien Flament of Molecular Imaging Research Center (MIRCen, CEA), Fontenay-aux-Roses, France, will present an introduction to the theoretical background of Chemical Exchange Saturation Transfer (CEST) imaging and its potential in neurodegenerative disease research. 

Key topics:

  • Theoretical considerations
  • Basic Kit for CEST protocol
  • CEST-MRI applications
  • Future of CEST imaging


Find Out More


Dr. Julien Flament, Research Engineer, Molecular Imaging Research Center (MIRCen, CEA), France

Date: Thursday 16th
February 2017


Session 1   10:00amBerlin Time 
  5:00pmBeijing Time
 
Session 2   11:00amBoston Time
5:00pm Berlin Time

 

Dr. Julien Flament

Dr. Julien Flament's expertise includes CEST imaging and the study of brain metabolism using NMR (nuclear magnetic resonance) spectroscopy and CEST imaging.  He is currently head of the NMR platform at MIRCen (CEA, Fontenay-aux-Roses).

 

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